By Dr. Baker (ND)
Anemia can be a sign of an underlying health imbalance. Research indicates that the causes of anemia range from genetic, hormonal, nutritional to environmental, and each factor requires a targeted approach for effective treatment.
Hormonal Influences
Hormones from the thyroid gland play a vital role in red blood cell production. Hypothyroidism is linked to an increased anemia risk, with a 2018 study highlighting that individuals with hypothyroidism are nearly twice as likely to develop anemia. Thyroid hormones may help to stimulate erythropoietin production, which aids red blood cell formation—a process documented in research from 2017.
Nutritional Deficiencies
Iron
Iron deficiency is one of the most common nutritional causes of anemia. Our clinic completes a comprehensive iron panel that checks several different markers of iron in the body.
Vitamin B12 and Folate
Both vitamin B12 and folate are critical for red blood cell formation.
Deficiencies in these nutrients often lead to megaloblastic anemia, a condition where red blood cells are larger and fewer in number. Supplementation and dietary adjustments can effectively address these deficiencies.
Vitamin D
Low vitamin D is another nutritional factor associated with anemia. In a 2016 study, individuals with low vitamin D were found to have a higher risk of anemia. This relationship underscores the importance of maintaining adequate vitamin D levels for overall health.
Studies have found many more nutrients that appear to be related to anemia. We can provide a full nutritional testing panel to check for underlying deficiencies that may be causing anemia.
Genetic Factors
Certain conditions may affect red blood cell stability, causing red blood cells to be damaged in some individuals. Testing for genetic causes can be helpful when traditional anemia treatments prove ineffective.
Inflammatory and Autoimmune Influences
Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP)
ESR and CRP are markers of inflammation, which can be elevated in autoimmune diseases and chronic inflammatory conditions. An elevated ESR may indicate conditions like inflammatory bowel disease, which has been associated with anemia. CRP levels can also indicate underlying autoimmune activity or infections that contribute to anemia.
Rheumatoid Factor
Rheumatoid arthritis (RA) is another autoimmune condition linked to anemia. Testing for rheumatoid factor helps identify RA as a potential cause, enabling targeted treatment.
Environmental and Heavy Metal Exposure
Lead Levels
Environmental factors, especially lead exposure, have been strongly associated with anemia. A recent 2024 study showed that mildly elevated blood levels increased anemia risk, and a 2022 study found nearly triple the risk at the highest blood levels. Our clinic can complete heavy metal screening for those who have already completed testing for other causes.
Conclusion
Identifying the specific cause of anemia through comprehensive testing is essential. By assessing genetic, hormonal, environmental, nutritional, and inflammatory factors, our clinic can create a personalized treatment approach to address anemia at its root.
Comprehensive testing and individualized therapies not only help manage symptoms but also foster long-term health improvements. Our goal is to support patients with an in-depth analysis and evidence-based interventions to achieve a balanced, healthier life.
